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Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma.

The triamterene and hydrochlorothiazide components of MAXZIDE and MAXZIDE-25 MG are well absorbed and are bioequivalent to liquid preparations of the individual components administered orallyFood does not influence the absorption of triamterene or hydrochlorothiazide from MAXZIDE or MAXZIDE-25 MG tabletsThe hydrochlorothiazide component of MAXZIDE is bioequivalent to single entity hydrochlorothiazide tablet formulations.

Triamterene is a potassium-conservingantikaliureticdiuretic with relatively weak natriuretic propertiesIt exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogenWith this actiontriamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazideTriamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison's diseasei.ewithout aldosteroneTriamterene's onset and duration of activity is similar to hydrochlorothiazideNo predictable antihypertensive effect has been demonstrated with triamterene.

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