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The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies

Results showed that the onset of noticeable increased iris pigmentation occurred within the first year of treatment for the majority of the patients who developed noticeable increased iris pigmentationPatients continued to show signs of increasing iris pigmentation throughout the five years of the studyObservation of increased iris pigmentation did not affect the incidencenatureor severity of adverse eventsother than increased iris pigmentationrecorded in the studyIOP reduction was similar regardless of the development of increased iris pigmentation during the study.

Latanoprost is a colorless to slightly yellow oil that is very soluble in acetonitrile and freely soluble in acetoneethanolethyl acetateisopropanolmethanoland octanolIt is practically insoluble in water.

This medication may slowlyover months to yearscause brown discoloration of the colored portion of the eyeirisIf you are using latanoprost in only one eyeonly that iris may change colorThis color change may be permanent but the long-term effects are uncertainNotify your doctor if this occurs and schedule regular eye exams to monitor it.

Advise patients that if they develop an intercurrent ocular conditione.gtrauma or infectionor have ocular surgeryor develop any ocular reactionsparticularly conjunctivitis and eyelid reactionsthey should immediately seek their physician's advice concerning the continued use of the multiple-dose container.

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