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HepaticAspartate transaminaseASTand/or alanine transaminaseALTvalues exceeded twice the upper limit of normal in approximately 1to 2of 723 patients receiving ZOFRAN and cyclophosphamide-based chemotherapy in US clinical trialsThe increases were transient and did not appear to be related to dose or duration of therapyOn repeat exposuresimilar transient elevations in transaminase values occurred in some coursesbut symptomatic hepatic disease did not occurThe role of cancer chemotherapy in these biochemical changes is unclear.

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As the class name suggestsZofran targets 5-HT3 receptors in the bodyThese receptors exist in both the central and peripheral nervous systemand when joined with a neurotransmitter called serotoninthey can cause nausea and vomiting.

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the combo of vistaril 25 mg, zofran 4 mg, and meclizine 25 mg did not seem to help control the nausea.