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Elevations in serum potassium have been observed in some patients treated with ACE inhibitorsincluding lisinoprilPatients at risk for the development of hyperkalaemia include those with renal insufficiencydiabetes mellitusor those using concomitant potassium-sparing diureticspotassium supplements or potassium-containing salt substitutesor those patients taking other drugs associated with increases in serum potassiume.gheparinthe combination trimethoprim/sulfamethoxazole also known as co-trimoxazoleIf concomitant use of the above-mentioned agents is deemed appropriateregular monitoring of serum potassium is recommendedsee section 4.5

When combined with other antihypertensive agentsadditive falls in blood pressure may occurConcomitant use of glyceryl trinitrate and other nitrates or other vasodilators may further reduce the blood pressure.

Take Zestoretic exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your doseDo not take this medicine in larger or smaller amounts or for longer than recommended.

You may also need to avoid taking Zestoretic with aliskiren if you have kidney disease.

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you should not use this medicine if you are allergic to hydrochlorothiazide hctz, hydrodiuril, lotensin hct, zestoretic, and others or triamterene dyrenium , or if you have kidney disease or are unable to urinate; you have high potassium levels hyperkalemia ; you are taking diuretics similar to triamterene, such as amiloride midamor, moduretic , spironolactone aldactone, aldactazide ; or you are taking potassium supplements unless your doctor tells you to .